Hydrocodone (Zohydro ER)

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SKU: Hydrocodone (Zohydro ER) Category:
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Zohydro ER | Hydrocodone bitartrate extended release capsules 

Medication Class: Opioid analgesic
Manufacturer: Zogenix, Inc.
Approval Date: October 25, 2013

What is Zohydro ER 

Zohydro ER contains hydrocodone which is a strong, long-acting narcotic pain reliever similar to oxycodone (Oxycontin), fentanyl, and morphine. It binds to opiate receptors in the central nervous system (CNS) including brain and spinal cord to alter how the body responds to pain.

What is Zohydro ER used for

Zohydro is an oral prescription medication used to treat constant pain. This drug is only approved for very severe and long-term pain that cannot be relieved by other drugs.

How well does Zohydro ER work

In a clinical study of Zohydro ER in 302 subjects with moderate to severe chronic low back pain treatment with Zohydro ER showed at least a 30% greater improvement in pain intensity as compared to placebo (67.5% vs. 31.1%) after 12 weeks.

What are interesting facts about Zohydro ER

  • Zohydro ER is a schedule II controlled medication. It is the first extended-release hydrocodone formulation that does not contain acetaminophen.
  • Zohydro ER is not used as needed like other hydrocodone-containing products.
  • It is equal to oxycodone and methadone in strength.
  • Zohydro ER is has a high abuse potential, just like oxycodone and other opioids, and there are petitions for the FDA to withdraw it from the market.
  • There is currently no generic version of Zohydro ER in the United States.

What is the dosage of Zohydro ER

Zohydro ER is available in strengths of 10 mg, 15 mg, 20 mg, 30 mg, 40 mg and 50 mg capsules.

Capsules should be swallowed whole with a lot of water every 12 hours. Do not chew, break, crush or dissolve before swallowing.

Start with 10 mg every 12 hours and increase by 10 mg every 12 hours every 3 to 7 days to achieve adequate pain control.

Zohydro ER may be taken with or without food at the same time of day. Take with food if stomach upset occurs.

What are the side effects of Zohydro ER

Constipation (If you do not have a bowel movement for 3 days, contact your doctor).


Drowsiness (Do not drive or operate dangerous machinery)





Abdominal pain

Zohydro ER may cause dangerous breathing problems. If you have slow or trouble breathing, seek medical care right away.

Zohydro ER exposes patients to the risks of abuse and addiction. Due to its formulation, abuse of this product can include crushing, chewing, snorting, or injecting, which may result in severe overdose or death. All patients should be monitored for signs of abuse, addiction, and misuse. Suddenly stopping Zohydro ER after long periods of usage may cause serious withdrawal symptoms. Using this drug during pregnancy for a long time may cause the baby to become dependent and experience life threatening withdrawal symptoms.

Zohydro ER Drug Interactions

Zohydro ER should not be taken with inhibitors of liver enzymes (e.g., atazanavir, bromocriptine, chloramphenicol, clarithromycin) that decrease breakdown of hydrocodone. Such combinations may result in large increases in drug concentration of hydrocodone leading to increased side effects.

Zohydro ER should not be taken with drugs (e.g., phenytoin, rifapentine, rifabutin) that increase the breakdown of hydrocodone in the liver. Such combinations may decrease blood levels and effects of hydrocodone.

Zohydro ER should not be taken with some drugs that affect the brain (e.g., alprazolam diazepam, zolpidem) or alcohol. Such combinations may intensify the effects of hydrocodone leading to decreased rate of breathing, low blood pressure, sedation or death.

Zohydro ER should not be taken with buprenorphine, butorphanol, nalbuphine, or pentazocine. Such combinations may decrease the pain relieving effect of Zohydro ER.

Taking Zohydro ER within 14 days with certain drugs such as phenelzine, selegiline, rasagiline, tranylcypromine can cause confusion and severe high blood pressure.

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I hoped to share with you some things which i collected in the process to aid with the preparation and generally being traveller. Many are pretty simple, But when you feel like a thousand miles out of the house, You cant find any wi fi and scarcely some cash on you, no tips can feel lifesavers! On Lanzarote island the one thing you need is sun screen to deal with the sizzling sunshine. the elements is usually sunny so when it rains the life halts there. Residents stay at home seal the doorway and panes and looking forward to the storm to pass.Lanzarote island is actually a windy destination. You will earliest notice it once your aircraft gets ready for landing. the north of the island is more breezy than the south. I you can’t bear the sand inside your heels and view try to get nearer to the south. Puerto del carmen is a sizzling and sun drenched place anytime of the year to enjoy with bars and eating to go out.Playa blanca is also a special area for most of the people with its amazing panorama and slow paced life. Its the favourite area of the familys and folks looking for a more downtempoed holiday vacation. The island primarily and greatest jazz pub the Blue Note is also found here which tells rather a lot about the people who come here too.Costa Teguise is the most windy of all of them and windsurfers like that rather a lot. should you be not into jazz or big gatherings then this is your resort for being on a getaway. you’ll see resort hotels, apartments, Pubs and eateries of any kind to pass your wedding ceremony after having a hard day at the outdoor pool.If you are more into bars than hiking under the scorching sun then you may need some cash too. Resorts are usually low cost so are the foodstuff and the drinks inside the bars. Most accommodations are offer meals which makes life much simpler in case you arent down into making your own meals or looking for eating places on daily basis to get a regular dish. Consider that many places wont allow credit card under a certain amount so keeping money in The island of lanzarote is truly a life saver.this article Lanzarote Shopping was originally posted on LanzaroteFlare.Shopping in LanzaroteLanzarote shopping guide may not be free of any bias and could heavily reflect personal experience.a celebrity or other Lanzarote’s shops need to comply with rules are not favourable with the average consumers. outcomes with well known brands being left out of the market resulting higher prices and low competition.Luckily the duopoly of HiperDino and Spar has been broken by Lidl some years ago providing the islanders with some real quality stock on cost-effective price points.its competitors just has stronger when Mercadona a long awaited Spanish food shop chain entered the market.It is not a known brand anywhere in Europe, I guess but it’s well praised here in Spain. The inhabitants of Lanzarote took the ferry each and every month to Fuertaventura only girls in spanish to shop there. It has quality brand label stock and average prices aimed at any nearby consumers.If you have a car it is where to shop for food on the island, the particular lack of well known brands makes it a bit confusing the first experience there.Lidl has slid to the second spot since Mercadona showed up. Actually it was empty for weeks after the big opening but it collected the pace now and opened a shop in Puerto Del Carmen, as well,actually. This seems bigger and more organised with the aired products actually in the shop not just somewhere “in transit,Both Lidl better proceeding by car, However it is reachable by public transport in Arrecife next to the smallest IKEA in the world or even on foot in Puerto Del spite of this, If cars are not at your disposal you stuck with Spar and HiperDino.Spar was the place for quality shopping prior to new shops arrived. It keeps rendering quality fresh stock like fruit, vegetables and fruits, this fish, Meat and famous European brands in its selection. at the tourists resorts there are smaller shops, Which work with a higher profit margin than you can find not in the towns so called Eurospars accessible mainly by cars.HiperDino or the rather pricey SuperDino around tourist areas have a reputation of having the lowest prices in the Canary Island. better, This certainly comes at a cost for an individual. I would recommend you to observe the prices of the items because it could be easily misleading. folks who wants see the price of an item, It could be currently cheaper than the promoted item next to it. Double check every fresh stock and meat to order it. It has the best selection of European and Spanish stock though.Chacon reputation is to provide best meat on the island. Most of the bars and dining establishments who use fresh meat for their dishes order from them, furthermore. within the, Most bars do not use fresh products so it is a rather narrow margin. If you like fresh quality food then this is where to source your ingredients.really, this should be a guide in itself but to cut a long story short:There are SALES each in Spain. summertime sales start around July here and end in August. Winter sales start after the 6th January and end in the March.I won’t get into just the lack of selection of shops or clothes itself now. There are 3 recognised places for shopping clothes in the island:In Playa Honda provides an air conditioned mall” However quite small to shop around.You may take a look at dock which houses some shiny shops mainly for the cruise ship visitors, unfortunately. The main street and surrounding area is highly popular and if you used to local fashion in all probability you’ll find something there. you’ll have to everything is closed on Sundays,And the closer end of the Strip in Puerto Del Carmen houses some gems of the island. If girl puts be disappointed by the other shops then don’t start here.complete tax in the Canary Island is 7%. sad to say, This is always reflected in the prices in Lanzarote as every item which reaches or leaves the island has research customs the dreaded aduanas, This could increase the money necessary for the items greatly. along with that there isn’t a great selection of items in the shops either.There are two shops in the island worth visiting if you are after gadgets. 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    A nurse reflects how to use a condom at Christa Medical Clinic in Jinja, Uganda. asking for: Lyndal Rowlands/IPS.

    Jinja, UGANDA, Sep 11 2016 (ips) Mambera Hellem tells her friends and neighbours about all forms of birth control, Yet russian chat despite their high HIV risk she knows any number of the women she speaks to will not use condoms.

    When I ask Mambera and her friend Kyolaba Amina whether it’s a woman or a man who decides to wear a condom, Kyolaba giggles softly at my situation,It is hard for a woman to initiate condom use because it will bring about questions of trust, proclaims Mambera. “The man would ask the wife if she doesn’t always trust him,

    Kyolaba though has deeper accusations, Adding that some men “purposely want to infect their wives,

    “i don’t know why men do that but I have seen a case where a woman and a man had discordant (HIV) Results but the man did not require to use condoms because before they were having unprotected sex, so why (definitely) next,

    Kyolaba (abandoned) and moreover Mambera (suitable) Both also speak to men about birth control, But Mambera says that the majority of men are “Not still interested,

    In a country where many myths abound around birth control and their side effects, the most popular forms of contraception for the women in this community aredepo provera “depo” And intrauterine software (IUD) augmentations.

    “You find some women who have children every year, So it is such women we get in touch with, affirms Mambera.

    Some women even prefer IUDs or depo because unlike condoms they can keep them secret to use husbands,And this is not the only aspect of their sex liveswhich women keepsecret, SaysKyolaba:

    “We do chat about HIV and tell the women to go for testing but many women are afraid to tell their husbands about this thing and they do secretly come for testing. Have an illustration of my neighbour who came to the clinic and tested positive but has kept this as a secret, Not told her husband, Because it might lead to violence in the home, she says.

    As I talk with Mambera and Kyolaba in the backyard of the Christa clinic in Jinja, Uganda, A group of women cradling babies on their laps watch as a nurse proves how to use a condom. The clinic serves a poor community near the banks of Lake Victoria and the fundamental cause of the Nile river providing free and low cost family planning services.

    Services honest safe music downloads are patchy at best inUganda which has one of the highest birth rates in the world: The average Ugandan women give birth to six babies during her lifetime.

    Uganda has a birth rate in the top 10 of countries international. financial information: Lyndal Rowlands/IPS.

    diverse, More connected with, Statistic has emerged in Uganda and other countries in Sub Saharan Africa large.

    Young women have grown to be HIV positive much younger than their male peers.

    want she is 21, A young woman in Uganda has a one in ten opportunity of being HIV positive.

    A young woman between your ages of 15 to 24 is more than twice as likely as a young man in the same age range to be HIV positive. as per the latest available statistics from 2011, 4.9 percent of ladies and girls between these ages will be HIV positive, in contrast to only 2.1 per of men, With sharp rises for girls between ages of 15 and 21.

    Without being allowed to influence whether their sexual partner wears a condom, These young ladies have little ability to protect themselves frombecoming HIV positive, Since condoms are the only form of contraception which also protects against sexually transmitted infections and diseases.

    medical professional Akinyele Eric Dairo, Officer in charge of the UN Family Planning Agency, UNFPA, on Uganda, Agrees with Mambera’s findings that women have less influence over condom use than men.

    “When you are looking for condom use, Men have more influence than the ladies, He also told IPS,Condom use brings about a sense of dependence on the part of a woman,

    Dairo addsthat the preference for other forms of contraceptive also reflects young unmarried women’s fears of pregnancy.

    “The effects of being pregnant manifest much faster than the effects of HIV and sexually transmitted infections, he states.

    Catherine a nurse at Jinja word of mouth hospital, Likes to put herself in the shoes of her young those. credit reports: Lyndal Rowlands/IPS.

    in view that Catherine, A nurse at Jinja the hospital puts it: “the major fear is pregnancy, they don’t know that they can get other problems,

    This may in part be because access to antiretroviral treatment hasgreatlyreduced not only the spread of HIV but also the the stigma around the condition. “People are praoclaiming that this is like being diabetic,Catherine informed me.

    Theincreased availability of antiretrovirals has ledto significant progress in fighting against AIDS in Sub Saharan Africa, However this progress could potentiallybe set back if prevention efforts among a demographic as large as adolescent girlscontinue to fail.

    may be whyLoyce Maturi, A 23 years old woman from Zimbabwe who has been HIV positive since she was 16, Was invited to deliver the keynote woman in russian address a high level United Nations meeting on AIDS in New York trapped on video tape.

    “Sharing my story I hope it reflected that as adolescents girls and young women we are vulnerable, for drinking and driving, Most infected and littered with the epidemics than any other age group, said Loyce.

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